- Study on college students’ willingness to inoculate COVID-19 vaccine based on bioinformatics and KAP analysis: Bioinformatics is a field that uses information technology to analyze and interpret biological data, and is being used to help with the research and development of vaccines for the novel coronavirus. China is offering free vaccinations to help control the spread of the virus.
- Monitoring and immunogenicity of SARS-CoV-2 vaccination of laboratory rhesus monkeys (Macaca mulatta): The availability of effective vaccines has allowed for the mitigation of protective measures against the SARS CoV-2 pandemic, but new variants of the virus have been found to have higher transmissibility and reduced vaccine efficacy, causing high infection rates during the third year of the pandemic. This poses a particular risk for unvaccinated individuals.
- What are the key pediatric public policy priorities as the COVID-19 pandemic persists: The COVID-19 pandemic is still ongoing and has had a significant impact on children. Vaccines protect both pregnant patients and newborns, and breastfeeding provides passive immunity. Long COVID has contributed to a crisis in pediatric mental health, and vaccines offer protection against this long-term complication. Vaccine misinformation is impacting compliance with maternal and pediatric COVID-19 immunization.
- Lung tropism in hospitalized patients following infection with SARS-CoV-2 variants from D614G to Omicron BA.2: This study examined the association between the severity of pneumonia in humans and SARS-CoV-2 variants. 514 patients admitted between February 2020 and August 2022 were analyzed to examine changes in the variants and tropism of SARS-CoV-2. Results showed that certain variants were associated with more severe pathogenesis.
- Is there a causal nexus between COVID-19 infection, COVID-19 vaccination, and Guillain-Barre syndrome: This review examines the effects of SARS-CoV-2 infection and COVID-19 vaccination on Guillain-Barre Syndrome (GBS), an immune-mediated inflammatory polyradiculoneuropathy that can lead to severe neurological disability.
- Incidence determinants and serological correlates of reactive symptoms following SARS-CoV-2 vaccination: This study investigated the associations between reactive symptoms following SARS-CoV-2 vaccination and serologic responses to vaccination in 9003 adults from the UK general population. Titres of combined IgG/IgA/IgM responses to SARS-CoV-2 spike (S) glycoprotein were determined in eluates of dried blood spots collected before and after vaccination. Results showed that participants who experienced reactive symptoms had higher serologic responses to SARS-CoV-2 compared to those who did not experience any symptoms.
- Identification of SARS-CoV-2 M(pro) inhibitors containing P1′ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2: Two small molecules, TKB245 and TKB248, have been identified as orally available inhibitors of the main protease (M(pro)) of SARS-CoV-2. These molecules have been shown to significantly reduce the infectivity and replication of various SARS-CoV-2 strains.
- Report on fraying resilience among the Ontario Registered Practical Nurse Workforce in long-term care homes during COVID-19: This study aimed to describe the personal and professional resilience of RPNs working in long-term care (LTC) homes during the COVID-19 pandemic by using an open cross-sectional online survey containing the Connor-Davidson Resilience Scale and Resilience at Work Scale.
- Distressed Work: Chronic Imperatives and Distress in Covid-19 Critical Care: This ethnographic study introduces the term “distressed work” to describe the emergence of chronic frictions between moral imperatives for health care workers to keep working and the dramatic increase in distress during the Covid-19 pandemic. Interviews and observant participation conducted in a hospital intensive care unit reveal how health care workers connected job duties with extraordinary emotional, physical, and moral burdens.
- Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children: Research on life-threatening influenza has revealed that inborn errors of type I interferon immunity and neutralizing autoantibodies against type I interferons are underlying critical COVID-19 in up to 5% of cases.
- Impact of the COVID-19 pandemic on cancer care in Ireland – Perspectives from a COVID-19 and Cancer Working Group: The onset of the COVID-19 pandemic in Ireland caused disruptions to cancer services due to prioritization of COVID-19 care, staff shortages, and reluctance among people with suspicious symptoms to attend for evaluation.
- Editorial for “Post COVID-19 Syndrome in Patients with Asymptomatic/Mild Form”: SARS-CoV-2, first reported in December 2019, is a novel virus that has infected many people around the world.
- COVID-19 Vaccination and Alcohol Consumption: Justification of Risks: The roll-out of vaccinations against COVID-19 began in January 2021, and since then, the consumption of alcoholic beverages has increased globally despite the gradual relaxation of quarantine restrictions.
- Changes in Etiology and Clinical Outcomes of Pleural empyema during the COVID-19 Pandemic: This study compared the incidence, etiology and outcomes of patients admitted for pleural empyema in Hong Kong in the pre-COVID-19 and post-COVID-19 periods. It found that Streptococcus pneumoniae was the predominant organism in <18-year-old patients, while Streptococcus anginosus, anaerobes and polymicrobial infections were more common in adults. Healthcare-seeking behavior changed during the pandemic, which may alter the epidemiology of pleural empyema.
- Saponins: Research Progress and Their Potential Role in the Post-COVID-19 Pandemic Era: In the post-COVID-19 pandemic era, it is necessary to take urgent measures to develop more effective therapies and drugs to counteract the negative global impacts caused by SARS-CoV-2 and its new infectious variants. Plant-derived saponins-glycoside-type compounds may be a potential solution, as they are constituted from a triterpene or steroidal aglycone and one or more sugar residues.
Daily News Pulse for March 13, 2023
Summary: Princeton students have seen an overall improvement in course satisfaction since the start of the COVID-19 pandemic. In Japan, many people are still wearing masks despite the government’s easing of guidelines.