- Psychosocial changes during COVID-19 lockdown on nursing home residents, their relatives and clinical staff: a prospective observational study: This study aimed to analyze the impact of COVID-19 lockdown on psychosocial factors of nursing home residents, relatives, and clinical staff.
- The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation: RNF5, an E3 ligase, interacts with and catalyzes the ubiquitination of the coronavirus envelope protein (E) on the 63rd lysine, leading to its degradation and providing a potential target for therapeutics against COVID-19.
- Tenofovir Disoproxil Fumarate Reduces the Severity of COVID-19 in Patients with Chronic Hepatitis B: This study analyzed the severity of COVID-19 in adult patients with chronic hepatitis B (CHB) on tenofovir hydroxyl fumarate (TDF) or entecavir (ETV). Results showed that patients on TDF had a lower risk of COVID-19 and hospitalization than those given ETV.
- Evaluation of the risk of SARS-CoV-2 infection and hospitalization in vaccinated and previously infected subjects based on real world data: This study aimed to investigate the joint protective effect of a previous SARS-CoV-2 infection and vaccination on the risk of a new infection and hospitalization. Two case-control studies were conducted within a cohort of COVID-19 patients in Vercelli, Italy, to estimate the risk of infection and hospitalization. Each new infection and hospitalization was matched with up to 4 disease-free subjects.
- Bilateral Persistent Placoid Maculopathy Following COVID-19 Vaccines: Real or Coincidence: Researchers report the first case of bilateral persistent placoid maculopathy (PPM) following COVID-19 vaccinations in a 58-year-old man who experienced decreased vision 2 weeks after the second dose of AstraZenaca(R) ChAdOx1-S/nCoV-19 vaccine. Fundus examination revealed bilateral well-delineated whitish plaque-like macular lesions involving the fovea.
- Discharge Disposition and Clinical Outcomes of Patients Hospitalized with COVID-19: Researchers conducted a retrospective chart review of adult patients with positive COVID-19 PCR tests in multiple hospitals to determine predictors of rehabilitation needs in those suffering from long-term sequelae of the virus.
- SSRIs differentially modulate the effects of pro-inflammatory stimulation on hippocampal plasticity and memory via sigma 1 receptors and neurosteroids: Researchers studied the potential mechanisms of anti-inflammatory effects of SSRIs, such as fluvoxamine, in a rat hippocampal slice model of pro-inflammatory stress. We found that fluvoxamine and other SSRIs activated sigma 1 receptors (S1Rs), which may be responsible for their anti-inflammatory effects.
- Lung fibrosis: Post-COVID-19 complications and evidences: COVID-19 patients receiving long-term treatment are at a higher risk of developing Pulmonary Fibrosis due to increased oxidative stress, inflammation, and elevated production of fibrotic proteins.
- Persistent physical symptoms after COVID-19 infection and the risk of Somatic Symptom Disorder: This study assessed the frequency of persistent physical symptoms and Somatic Symptom Disorder (SSD) in patients with confirmed COVID-19, and examined the associated factors.
- Post-COVID-19 interstitial lung disease: Insights from a machine learning radiographic model: In this retrospective study, researchers included consecutive patients who had been evaluated 3 months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection between 01/02/2021 and 12/5/2022. High-resolution computed tomography was evaluated through Imbio machine learning radiographic models to evaluate post-COVID-19 interstitial lung disease (ILD).
Daily News Pulse for March 13, 2023
Summary: Princeton students have seen an overall improvement in course satisfaction since the start of the COVID-19 pandemic. In Japan, many people are still wearing masks despite the government’s easing of guidelines.