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Daily News Pulse for January 27, 2023

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Summary: The FDA has voted to update all Covid-19 vaccines to contain the same ingredients as the two-strain shots used as booster doses. Studies have shown that the SARS-CoV-2 spike protein can cross the blood-brain barrier, leading to cognitive impairment and inflammation. CDC data shows that COVID cases, deaths, and hospitalizations have stabilized after a small surge around the holidays, but there is still uncertainty about long COVID.
  • Emergency Physicians and Advanced Practice Providers with … – Physician’s Weekly: This study sought to determine the prevalence of unknown COVID-19 infections among emergency physicians and Advanced Practitioner Providers (APPs) working in emergency departments (EDs). The results showed that the prevalence of unknown COVID-19 infection was low among the cohort of EPs and APPs. The authors concluded that the introduction of COVID-19 vaccinations had a positive effect on reducing the prevalence of unknown COVID-19 infections.
  • CDC Launches Website to Help Consumers Find Free COVID-19 … – HSToday: Testing for COVID-19 is available at pharmacies, commercial laboratory sites, community sites, and retail locations. The CDC has launched a COVID-19 Testing Locator website to help consumers find free testing sites near them. Tests offered may include laboratory-based nucleic acid amplification tests (NAATs) and rapid antigen point-of-care (POC) testing, with results typically provided within 1-3 days.
  • FDA vaccine advisers vote to harmonize Covid-19 vaccines in the United States – CNN: The FDA’s independent expert panel voted unanimously to update all Covid-19 vaccines to contain the same ingredients as the two-strain shots used as booster doses. This would make young children and others who haven’t been vaccinated eligible for two-strain vaccines that more closely match the circulating viruses as their primary series. The FDA must approve the recommendation before it goes into effect.
  • Disruption of the blood-brain barrier due to long COVID – News-Medical.Net: Studies have shown that the SARS-CoV-2 spike protein can cross the blood-brain barrier, leading to cognitive impairment and inflammation. This has been observed in deceased SARS-CoV-2 patients, as well as in rodent models.
  • ‘Microclots’ could help solve the long COVID puzzle – National Geographic UK: Physiologist Etheresia Pretorius and her colleagues at Stellenbosch University in South Africa have proposed that microclots, tiny blood clots caused by the SARS-CoV-2 spike protein, may be linked to long COVID and its lingering symptoms. Their follow-up study showed that the body’s natural clot-busting process does not always effectively break down these clots.
  • Long COVID: What Do the Latest Data Show? – KFF: CDC data shows that COVID cases, deaths, and hospitalizations have stabilized after a holiday surge. There is still uncertainty about long COVID and whether there will be increased cases following the holiday bump. Vaccines may reduce the likelihood of getting long COVID, or reduce its severity among those who already have it, but only 15% of the population has been vaccinated so far.
  • FDA yanks EUA for AstraZeneca’s Evusheld as COVID variants … – MM+M Online: The FDA has revised the Emergency Use Authorization (EUA) for AstraZeneca’s Evusheld, noting that the drug is not authorized for use in the U.S. until further notice due to the ongoing evolution of COVID-19 subvariants. Hospitals, health systems and healthcare providers should retain existing supplies of Evusheld in case future subvariants are found to be neutralized by the treatment.
  • US moves to simplify Covid vaccines into yearly dose to target variants – The Guardian: The FDA is asking its scientific advisers to help develop a plan for switching to yearly Covid-19 booster shots for most Americans, in order to simplify the use of current vaccines and protect against the rapidly mutating virus. The advisory panel mostly agreed with the FDA’s approach.

Daily News Pulse for March 13, 2023

Summary: Princeton students have seen an overall improvement in course satisfaction since the start of the COVID-19 pandemic. In Japan, many people are still wearing masks despite the government’s easing of guidelines.

Daily Research Pulse for March 13, 2023

Summary: A systematic review examines the prevalence of nurses and physicians leaving their positions in European hospitals and the factors influencing job retention among them. Researchers found that 31.4% of hospitalized patients with cardiac problems and suspected COVID-19 had PTSD during waves 2-5 of the pandemic.

Daily News Pulse for March 10, 2023

Summary: A pilot study by Brigham and Women’s Hospital found that nasal administration of the anti-CD3 monoclonal antibody Foralumab can modulate T cell inflammatory responses in COVID-19. The Washington State Department of Health is ending its free at-home testing program Say Yes! COVID Test on May 11. California Governor Gavin Newsom has tested positive for COVID-19 after a personal trip to Baja California.

Daily Research Pulse for March 10, 2023

Summary: Researchers examined the clinical, laboratory, and cardiac indicators of multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (Covid-19), and the experiences and behaviors of adults with positive SARS-CoV-2 test results or who were exposed to a confirmed case of COVID-19.

Daily News Pulse for March 09, 2023

Summary: California Governor Gavin Newsom tested positive for COVID-19 and will be in isolation for the next five days. After recovering from a mild case of COVID, many people have developed long-term gastrointestinal symptoms. The US House of Representatives held a public hearing to explore the origins of the virus.