- COVID-19 vaccine potency and breadth improved by nanoparticle-conjugated adjuvants – News-Medical.Net: In a recent study, researchers designed a nanoparticle (NP)-conjugated toll-like receptor 9 (TLR9) agonist to improve the adjuvanticity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines. The TLR9 agonist cytosine phosphoguanine (CpG) activates intracellular signaling leading to antigen-presenting cell (APC) and B cell activation. NPs sized 20 – 100 nm efficiently drain into lymph nodes through the lymphatic system, where resident APCs take up NPs without needing specific cell-targeting ligands.
- What is the long-term cognitive impact of COVID-19, and what are its predictors? – News-Medical.Net: Scientists have found that some people who have had COVID-19 may have problems with their thinking and memory even a year after infection. This is called “long COVID.” The study found that people who were older, had a lower education level, and had more severe symptoms were more likely to have these problems.
- Trouble sleeping a common symptom of long-COVID – DW (English): There are many reasons why people with COVID-19 might have trouble sleeping. Studies have found that sleep problems in patients with coronavirus infections can persist after the acute phase of the disease is over. These problems include insomnia and difficulty staying asleep through the night.
- ‘I want people to see us’: A writer gives voice to long Covid and … – STAT: Kristin Houlihan, 38, got sick in March 2020 with a virus she assumes was Covid. She had symptoms like night sweats and extreme temperature swings that never went away. She spent the next year or so living life, raising her children, but also noticing that some things were different. She’d come home from doing groceries and be “unusually tired,” or be shaky after taking her kids to the park. “I assumed it was Covid anxiety, but my therapist and I concluded together that there was something physical going on,”…
- Four distinct subtypes of long COVID defined in machine learning … – New Atlas: The new study found that there are four types of long COVID, which are determined by the symptoms the patients have. The four types are cardiac and renal problems, respiratory problems, sleep and anxiety problems, and gastrointestinal problems.
- Long COVID stemmed from mild cases of COVID-19 in most people, according to a new multicountry study – WJW FOX 8 News Cleveland: COVID-19 can have long-lasting effects on people’s health, even if it is a mild case. This was found in a recent study of long COVID-19 cases. Long COVID is defined as the continuation or development of symptoms three months after the initial infection from SARS-CoV-2. These symptoms last for at least two months with no other explanation. The study found that 90% of people with long COVID had at least one symptom after 3 months and that 63% had at least 3 symptoms.
- “Long-Covid” Discrimination Lawsuit Filed Against Lifespan by … – GoLocalProv: A former employee of Lifespan has filed a lawsuit in federal court alleging disability discrimination, after she said she was fired after suffering from long-COVID.
- Newest COVID-19 variant XBB.1.5 spreading – KOAT New Mexico: A new COVID-19 variant, called XBB.1.5, is spreading throughout the U.S. and causing some concern in New Mexico. Dr. Jason Mitchell, the chief medical officer of Presbyterian health care, said that the variant is taking over and is highly transmissible. XBB.1.5 accounts for more than 27 percent of COVID-19 cases nationwide.
- NY saw nearly 1,600 COVID deaths as XBB.1.5 variant emerged – The Journal News: Since December 1, 1600 New Yorkers have died from COVID-19. This is due to a new, highly contagious variant called XBB.1.5. Experts are now warning that outbreaks may only get worse during a post-holiday wave.
Summary: Governor John Carney has tested positive for COVID-19 and is working from home. The 7-day average of new cases in Delaware is 135, with 158 hospitalizations. A new study has found that 71% of people with long COVID required medical treatment or were unable to work for six months or more. The FDA has withdrawn emergency use authorization for the COVID-19 antibody drug Evusheld due to its ineffectiveness against the Omicron variants now dominating the US.