- Critical review of conformational B-cell epitope prediction methods: Computational methods can predict conformational B-cell epitopes, which would improve disease diagnostics, drug design, and vaccine development.
- Relationships between social vulnerability and COVID-19 vaccination coverage and vaccine effectiveness: There is a relationship between social vulnerability and vaccine effectiveness for COVID-19. Factors such as exposure risk and access to health care may contribute to this relationship.
- Pre-vaccination glucose time in range correlates with antibody response to SARS-CoV-2 vaccine in type 1 diabetes: Patients with type 1 diabetes and poor glucose control are at increased risk for mortality from COVID-19. This study looked at the effect of pre-vaccination glucose control on antibody response to the SARS-CoV-2 vaccine BNT162b2 in T1D patients. 26 patients were studied, 21 of which received two doses of the vaccine 21 days apart. All patients were followed for six months with regular evaluation of SARS-CoV-2 antibodies and glucose control. The results showed that pre-vaccination glucose control did not affect the antibody response to the vaccine.
- Real world research on transcranial magnetic stimulation treatment strategies for neuropsychiatric symptoms with long-COVID in Japan: The number of patients with long-COVID is increasing, and this study investigates the effects of transcranial magnetic stimulation (TMS) treatment on neuropsychiatric symptoms caused by long-COVID. The study found that the TMS treatment protocol was effective in reducing symptoms in patients who sought TMS treatment for long-COVID.
- Cerebrospinal fluid biomarkers in SARS-CoV-2 patients with acute neurological syndromes: Our present aim was to study a panel of biomarkers of neuroinflammation and neurodegeneration in the cerebrospinal fluid (CSF) of NeuroCOVID patients. We retrospectively collected clinical and CSF biomarkers data from 24 NeuroCOVID adults seen at the University Hospitals of Geneva between March and May 2020. Our study found that a panel of biomarkers of neuroinflammation and neurodegeneration is associated with acute brain injury in SARS-CoV-2 patients. These findings may help to prevent long-term neurological sequelae.
- Previously independent patients with mild-symptomatic COVID-19 are at high risk of developing cognitive impairment but not depression or anxiety: The study found that hospitalized subjects with mild symptomatic COVID-19 had cognitive impairments. Patients who were independent at home before the infection and had no neurological diseases were recruited. The study found that these patients had cognitive impairments.
- COVID-19 associated development of antibody mediated rejection in orthotopic heart transplantation patients: Despite improvements in medical management and vaccination efficacy, solid organ transplant candidates remain at increased risk for complications post COVID-19, including organ rejection. We describe the development of antibody mediated rejection with or without cellular rejection in heart transplant recipients and previous COVID-19 infection or vaccination.
- Disruptions in Accessing Women’s Health Care Services: Evidence Using COVID-19 Health Services Disruption Survey: The Coronavirus pandemic has caused many disruptions, including in the areas of family planning and women’s health. This study looks at the possible impacts of the pandemic on these areas.
- Association of preexisting psychiatric disorders with post-COVID-19 prevalence: a cross-sectional study: This study looked at the association of preexisting psychiatric disorders with post-COVID-19. They found that a total of 6015 (response rate = 77.5%) COVID-19 survivors were surveyed using a self-administered questionnaire from July to September 2021. Poisson regression analysis with robust error variance was performed to estimate post-COVID-19 prevalence ratios (PRs) with 95% confidence intervals (CIs).
- COVID ‘variant soup’ is making winter surges hard to predict
- Large interfacial relocation in RBD-ACE2 complex may explain fast-spreading property of Omicron: The Omicron variant of SARS-CoV-2 emerged in South African in late 2021. This variant has a large number of mutations, and is regarded as the fastest-spreading Covid variant.
- The influence of new SARS-CoV-2 variant Omicron (B.1.1.529) on vaccine efficacy, its correlation to Delta variants: A computational approach: The new COVID variant in Botswana has more than 30 mutations in spike and many other in non-spike proteins. It is far more than any other SARS-CoV-2 variant accepted as a variant of concern by the WHO and officially named Omicron. Scientists and the general public are concerned about this new variant.
Daily News Pulse for April 05, 2023
Summary: The domestic box office is close to reaching pre-pandemic levels, with mid-budget films helping to bring moviegoers back. Research has found that diabetes is a major factor in the severity of COVID-19 cases. The US government is planning to authorize booster doses of the vaccine for high-risk populations.