- In Silico Analysis Reveals the Inhibitory Potential of Madecassic Acid against Entry Factors of SARS-CoV-2: Coronavirus disease 19 (COVID-19) is a global health emergency caused by SARS-CoV-2 infection. The virus is highly contagious, affecting millions of people worldwide. SARS-CoV-2, with its trimeric spike glycoprotein, interacts with the angiotensin-converting enzyme 2 (ACE2) receptor and other co-receptors like basigin to invade the host cell. Moreover, certain host proteases like transmembrane serine proteases, furin, neuropilin 1 (NRP1), and endosomal cathepsins are involved in the processing of the viral spike glycoprotein and are potential targets for therapeutics.
- A systematic review of videoconferencing in health professions education: the digital divide revisited in the COVID-19 era: During the COVID-19 pandemic, many educators shifted from traditional lectures to videoconferencing. This systematic review explored the use of videoconferencing as a teaching tool in response to the pandemic as well as issues related to digital equity and inclusion.
- Epidemic responses under uncertainty: We examine how policymakers react to a pandemic with uncertainty around key epidemiological and economic policy parameters by embedding a macroeconomic SIR model in a robust control framework. Uncertainty about disease virulence and severity leads to stricter and more persistent quarantines, while uncertainty about the economic costs of mitigation leads to less stringent quarantines. On net, an uncertainty-averse planner adopts stronger mitigation measures.
- Impact of time to diagnosis on the occurrence of cardiogenic shock in MIS-C post-COVID-19 infection: In the study, children meeting the World Health Organization MIS-C criteria were included. A long time to diagnosis was defined as more than 7 days from symptom onset to the first outpatient or emergency department visit. The primary outcome was the occurrence of cardiogenic shock. The study found that a long time to diagnosis was associated with the occurrence of cardiogenic shock.
- Aromatherapy and Fermented Fruits for Long COVID: Placebo-Controlled Placebo Trials
- Mechanical ventilation for COVID-19: Outcomes following discharge from inpatient treatment: MV is used to treat patients with severe coronavirus disease 2019 (COVID-19), but little is known about the long-term health implications of this treatment. Our objective was to determine the association between MV for treatment of COVID-19 and likelihood of hospital readmission, all-cause mortality, and reason for readmission. This study was a longitudinal observational design with electronic health record (EHR) data collected between 3/1/2020 and 1/31/2021.
- Clinical profile and the extent of residual myocardial dysfunction among patients with previous coronavirus disease 2019: COVID-19 patients often continue to have symptoms even after recovering, and this study looked at what those symptoms are and how they compare to a control group. 472 previous COVID-19 patients and 100 controls were studied. Results showed that many COVID-19 patients have lasting symptoms, including fatigue, chest pain, and anxiety. They also often have abnormal echocardiography findings.
- Does China Pakistan Economic Corridor become an avenue to achieve sustainable development goal no. 2 (food security) in Pakistan: Under the condition of COVID-19: The post-Covid-19 world is moving towards stakeholder thinking, which means finding sustainable solutions to problems like food security. The China Pakistan Economic Corridor could be a way for Pakistan to get help with the effects of the pandemic while also working on solutions to other problems.
- COVID ‘variant soup’ is making winter surges hard to predict
- Large interfacial relocation in RBD-ACE2 complex may explain fast-spreading property of Omicron: The Omicron variant of SARS-CoV-2 emerged in South African in late 2021. This variant has a large number of mutations, and is regarded as the fastest-spreading Covid variant.
- The influence of new SARS-CoV-2 variant Omicron (B.1.1.529) on vaccine efficacy, its correlation to Delta variants: A computational approach: The new COVID variant in Botswana has more than 30 mutations and is far different than any other SARS-CoV-2 variant. Scientists are concerned about the structural modification caused by the mutations and how it will affect interaction with the hosts’ neutralizing antibodies.
Daily News Pulse for April 05, 2023
April 5, 2023
Summary: The domestic box office is close to reaching pre-pandemic levels, with mid-budget films helping to bring moviegoers back. Research has found that diabetes is a major factor in the severity of COVID-19 cases. The US government is planning to authorize booster doses of the vaccine for high-risk populations.
