- Investigation on the interaction mechanism of different SARS-CoV-2 spike variants with hACE2: insights from molecular dynamics simulations: Since the COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), SARS-CoV-2 has evolved by acquiring genomic mutations, resulting in the recent emergence of several SARS-CoV-2 variants with improved transmissibility and infectivity relative to the original strain. An underlying mechanism may be the increased ability of the mutants to bind the receptor proteins and infect the host cell.
- ‘You get looked at like you’re failing’: A reflexive thematic analysis of experiences of mental health and wellbeing support for NHS staff: The COVID-19 pandemic has put a strain on NHS staff. We interviewed 48 healthcare workers from 18 NHS Trusts in England about their experiences of workplace health and wellbeing support during the pandemic. We found that some staff feel there is a stigma around seeking help.
- Title: Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID-19 severity: COVID-19 severity is associated with neutrophilia and lymphopenia, which point to systemic molecular cell cycle alterations. However, the landscape of cell cycle alterations in COVID-19 remains primarily unexplored.
- Outpatient treatment of Covid-19 with metformin, ivermectin, and fluvoxamine and the development of Long Covid over 10-month follow-up: COVID-19 can lead to a chronic illness called Long Covid. The COVID-OUT study is testing three oral medications to see if they can help people with Long Covid.
- ‘You get looked at like you’re failing’: A reflexive thematic analysis of experiences of mental health and wellbeing support for NHS staff: NHS staff are under a lot of stress, which has been made worse by the COVID-19 pandemic. NHS Trusts provide health and wellbeing support services, but there has been little research into what staff think of these services. We interviewed 48 healthcare workers from 18 NHS Trusts in England about their experiences of workplace health and wellbeing support during the pandemic. We found that some staff feel stigma around seeking help, and that support services need to be more easily accessible.
- Psychoeconomic impact of the coronavirus pandemic on the general population in Saudi Arabia: a cross-sectional study: This study looked at the psychological and economic effects of the COVID-19 epidemic in Saudi Arabia. They found that people aged 19-49 were more likely to suffer financially from the COVID-19 epidemic.
- Methodological approaches to optimize multiplex oral fluid SARS-CoV-2 IgG assay performance and correlation with serologic and neutralizing antibody responses: Oral fluid (saliva) is a good alternative to blood for testing for SARS-CoV-2 IgG (a protein that shows if someone has had the virus before). However, because saliva is a different kind of sample than blood, it can be hard to get accurate results from tests. This study tried to improve the accuracy of a test for SARS-CoV-2 IgG in saliva. The study found that the test was more accurate when using a higher threshold for positive results and when qualifying samples based on how much saliva they contained.
- Corona Disease Anxiety and Health Related Behaviors: What Happened to Primgravida Women Post COVID-19: The COVID-19 pandemic has caused psychological and behavioral changes among pregnant women across the globe, which might have a devastating impact on the fetal and neonatal outcomes.
- Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis: Cases of young people developing myocarditis after getting a vaccine for the coronavirus have been reported around the world. This study looked at the blood of 16 patients who were hospitalized for myocarditis after getting the vaccine.
- COVID ‘variant soup’ is making winter surges hard to predict
- Large interfacial relocation in RBD-ACE2 complex may explain fast-spreading property of Omicron: The Omicron variant of SARS-CoV-2 emerged in South African in late 2021. This variant is faster-spreading than other Covid variants.
- The influence of new SARS-CoV-2 variant Omicron (B.1.1.529) on vaccine efficacy, its correlation to Delta variants: A computational approach: The new COVID variant in Botswana has many mutations and is a cause for concern. Scientists are studying the effects of the mutations and how they interact with the host’s neutralizing antibodies.
Daily News Pulse for April 05, 2023
Summary: The domestic box office is close to reaching pre-pandemic levels, with mid-budget films helping to bring moviegoers back. Research has found that diabetes is a major factor in the severity of COVID-19 cases. The US government is planning to authorize booster doses of the vaccine for high-risk populations.